Diagnosis and prognosis biomarkers in global health (FUN)

Diagnosis and prognosis biomarkers in global health (FUN)
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A bachelor of science is recommended to follow this MOOC.
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Diagnosis and prognosis biomarkers in global health (FUN)
Biomarkers are the subject of considerable interest by scientists and researchers worldwide: they determine the use of targeted treatments (a major therapeutic advance in medicine), allow to measure the evolution of a disease or to indicate a particular physiological event. The aim of this MOOC is to review the interest of biomarkers for public health, based in particular on the research activities of the thirty-three institutes of the Institut Pasteur international network.

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After a period of enthusiasm, it is clear that the development of reliable biomarkers is long and complex and must respect rigorous methodological constraints. Due to the extraordinary development of genomics and proteomics and the exposure of the Institut Pasteur international network (IPIN) to emerging diseases, the Institut Pasteur is particularly well-positioned to study the interest of biomarkers for diseases diagnosis and prognosis in global health.




This MOOC is organized into four chapters. The first chapter introduces the subject and delas with the definition and methodological aspects of biomarkers; the second chapter, based on targeted examples (HIV, arbovirus, malaria, tuberculosis, etc.), focuses on the use of biomarkers in infectious diseases. The third chapter is dedicated to biomarkers in oncology. The fourth chapter sheds light on the use of biomarkers in the context of non-communicable diseases (rare diseases, Alzheimer's disease, liver disease, etc.).

This MOOC revolves around two important points: first, the undeniable diagnostic, prognostic and / or therapeutic interest of biomarkers. At each stage of a patient’s care, from the diagnosis of a disease to its treatment, biomarkers are useful and make it possible to hope for a "personalized medicine". The second important point refers to the limits of most biomarkers: insufficient sensitivity or specificity; possible application to a subgroup of patients only, for a given pathology; short duration of their half-life, reducing their clinical relevance (due to the emergence of more effective biomarkers or therapeutic progress). Research on biomarkers remains essential to overcome these limitations, to define new combinations of different biomarkers and to optimize their performance and hence their use. We hope that this MOOC and the associated multiple-choice questions will clarify the use of bio-markers in tomorrow’s medicine and highlight both their advantages and limitations.


Course syllabus


Chap I : Introduction

Françoise Barré-Sinoussi : Biomarkers and IPIN

Stanislas Pol : What are we up to with biomarkers?

Antonin Ginguay : The role of CA 125 and HE4 in the history of biomarkers +

Catherine Larue : Validation of biomarkers

Arnaud Fontanet : Definition of a good biomarker from a statistical point of view

Amalio Telenti : Use of pharmacogenetics

Matthew Albert : Biomarkers: from research to industrial development


Chap II : Biomarkers in infectious diseases

Iryna Nikolayeva : Systems Biology Lab and Functional Genetics of Infectious Diseases Unit

Laetitia Velly : Early biomarkers for the diagnosis of bacterial infection in emergency departments

Yves Germani : biomarkers for meningitis diagnostics

Didier Ménard : Biomarks of resistance to artemisinin

Béatrice Jacquelin : Creation of diagnostic tools in case of outbreak : the Ebola example

Brigitte Gicquel : Biomarkers for multi-drug resistance tuberculosis

Elhem Yacoub : Biomarkers for Serodiagnosis of Human Mollicutes Infections

Sean Kennedy : Biomarkers of microbiota

John Hiscott : Biomarkers for patients infected with Human T cell Leukemia Virus

Desmukh Gopaul : A device for the detection of (re)-emerging arboviral diseases


Chap III : Biomarkers in oncology

Dominique Bellet : Biomarkers and therapeutic indications in oncology

Iradj Sobhani : Colon and Rectal Cancer (CRC) et Biomarkers

Pascal Pineau : Biomarkers and HCC


Chap IV : Biomarkers in metabolic and inflammatory diseases

Darragh Duffy : Ultrasensitive detection of protein biomarkers for diagnosis of rare diseases

Wilson Savino : biomarkers for non-communicable diseases : the case of Duchesne distrophy

Sofiane Samir Salah : biomarkers for non-communicable diseases : the case of rheumatoid arthritis

Vincent Chouraki : Biomarkers in Alzheimer

Cosmin Voican : Biomarkers of excessive alcoholic intake


Chap V : Conclusions

Sara Eyangoh : Development of biomarkers in IPIN – perspectives for biomarkers in the future

Marie-Astrid Vernet : Conclusion - Take home messages



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MOOC List is learner-supported. When you buy through links on our site, we may earn an affiliate commission.

Free Course
A bachelor of science is recommended to follow this MOOC.

MOOC List is learner-supported. When you buy through links on our site, we may earn an affiliate commission.