Innate Immunity (FUN)

Innate Immunity (FUN)
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Innate Immunity (FUN)
More than a century ago, Elie Metchnikoff established the bases of cellular innate immunity when he discovered the mechanism of phagocytosis. However, during most of the XXth century, adaptive immunity (also known as specific immunity) focused most of the interest of the researchers, until Charles Janeway and Polly Matzinger revisited the definition of immunology. What was called “non-specific immunity” was renamed “innate immunity”, and the understanding of the sensing of the exogenous or endogenous dangers signals, and their identification revolutionized our understanding of the early mechanism aimed to defend the integrity of the host against any type of attacks including pathogens.

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Nowadays, how bacteria, viruses, parasites and fungi are sensed by the infected host, have been mostly deciphered. Similarly, the mechanisms of the host involved to defend its integrity against infectious process have been decoded. This MOOC describes the players and the whole orchestra involved in innate immunity against pathogens.


Prerequisites

This MOOC targets people with a medical or scientific training background who are interested in all aspects of innate immunity: medical students, scientific Master II and PhD students (Immunology, Bacteriology, Parasitology, Virology…), post-doc, physicians, pharmacists, veterinarians, and all scientists working on bacteria, viruses, fungi and parasites, interested to learn more about the defense mechanism of the host against their favored bug.


Course syllabus


Week 1: Cellular players - part 1

Macrophages

Neutrophils

NK cells

NKT cells

Innate lymphoid cells


Week 2: Cellular players - part 2

T γ/δ lymphocytes

Th17 lymphocytes

Treg lymphocytes

Dentritic cells

Mast cells


Week 3: Molecular players - part 1

PAMPs

DAMPs (alarmins)

PRRs : TLR

PRRs : NLR

PRRs : RLR


Week 4: Molecular players - part 2

The complement system

Cytokines

Chemokines

Anti-microbial peptides


Week 5: Host-pathogen interactions

Anti-infectious role of cytokines

Innate immunity and bacterial infection

Innate immunity and viral infection

Innate immunity and parasitic infection

Innate immunity against fungal infection

Microbial strategies against the immune system

Mucosal innate immunity


Week 6: Regulation of innate immune response

Sepsis/ an overwhelmed innate immune response

Regulation of the immune system by the central and peripheral nervous system

Links between innate and adaptive immunity

Evolutionary genetics of the human innate immune system

Trained innate immunity

Parameters influencing immune responses


Suggested Readings

Toll-Like Receptors (TLRs) and Innate Immunity

Mouse Models of Innate Immunity: Methods and Protocols



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