Persons with disabilities are frequently marginalized in society and face numerous challenges in the enjoyment of their human rights. In the past such challenges were seen as an unavoidable consequence of their impairments. More recently, the introduction of a human rights-based model of disability has contributed to a shift in perceptions and attitudes. Viewing disability from a human rights standpoint implicates a change in the way States and all sectors of society consider persons with disabilities: no longer as recipients of medical care and charity or objects of others’ decisions, but holders of rights. This free and open to all MOOC (Massive Open Online Course) provides participants with the knowledge and skills necessary to effectively approach disability from a human rights perspective. Drawing from expertise and examples at the global and national level, it offers a multidisciplinary and multifaceted overview of historical developments, main standards, key issues, and current challenges in this area of human rights protection.