Marc Birtwistle




Dr. Birtwistle is an Assistant Professor in the Department of Pharmacology and Systems Therapeutics and the Systems Biology Center New York.

Dr. Birtwistle is formally trained as a chemical engineer, and thus knowledgeable in a wide array of quantitative methods for mathematical modeling of physicochemical processes. During his doctoral work, he applied such methods to understanding cancer as a disease of deregulated control systems, particularly, the ErbB signaling network, which is dysfunctional in many types of human cancer. Such a so-called integrative systems biology approach focuses not on how individual genes and proteins affect the signaling network, but rather on how the connectivity between and states of players in the network create biological function, or in the case of cancer, disease. During this doctoral and consequently postdoctoral experience, Dr. Birtwistle was also trained as an experimental cell and molecular biologist to complement the quantitative modeling background, and thus brings an interdisciplinary approach to cancer research.

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Jan 23rd 2017

Learn about the technologies underlying experimentation used in systems biology, with particular focus on RNA sequencing, mass spec-based proteomics, flow/mass cytometry and live-cell imaging. A key driver of the systems biology field is the technology allowing us to delve deeper and wider into how cells respond to experimental perturbations. This in turns allows us to build more detailed quantitative models of cellular function, which can give important insight into applications ranging from biotechnology to human disease. This course gives a broad overview of a variety of current experimental techniques used in modern systems biology, with focus on obtaining the quantitative data needed for computational modeling purposes in downstream analyses.

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