M2O2C2 is an invitation to think carefully about how one thing changing affects something else. What is the "derivative" of a function of many variables? How can a curved object be approximated by a flat plane? What does the chain rule look like when many things are affecting many other things? How do we find an input which maximizes a function of many variables?
This is a first course in multivariable differential calculus, but along the way, we will also introduce a ton of linear algebra. The result is a course targeted at a student who has seen a bit of calculus and who is willing to learn about linear transformations and vectors; such a student will have the best possible vantage point from which to explore derivatives of functions of many variables.
More info: https://www.coursera.org/course/m2o2c2